Gelsolin



Gelsolin (GLS) is a protein regulator of actin assembly and disassembly. The images at the top and at the right correspond to one representative gelsolin structure, i.e. the human gelsolin (3ffn), it has dimeric form. It contains 6 homologous domains S1 to S6.

GLS
3ffn – hGLS – human

2fgh – hoGLS+ATP – horse

1d0n - hoGLS

2x1o, 1x1p, 1x1q – GLS nanobody - Llama

GLS domains S1-S3
3ffk – hGLS domains S1-S3+actin

1rgi - hoGLS domains S1-S3+actin

GLS domains S4-S6
1h1v - hGLS domains S4-S6+actin

1nph - GLS domains S4-S6+Ca – mouse

GLS domain S1
2ff3 - hGLS domain S1+N-WASP+actin

2ff6 - hGLS domain S1+Ciboulot domain 2+actin

1mdu - hGLS domain S1+chActin – chicken

1d4x - hGLS domain S1+CeActin+Mg-ATP – Caenorhabditis elegans

1esv - hGLS domain S1+rActin+latrunculin – rabbit

1eqy - hGLS domain S1+rActin

1yvn - hGLS domain S1+yActin (mutant) – yeast

1yag - hGLS domain S1+yActin

1t44 - hGLS domain S1-thymosin β-4 C-terminal fusion+rActin

1kcq – hGLS domainS1+Cd

1c0f - hGLS domain S1+DdActin+Ca-ATP - Dictyostelium discoideum

1c0g, 1dej - hGLS domain S1+DdActin (mutant)

3a5l, 3a5m, 3a5n, 3a5o - hGLS domain S1 (mutant)+DdActin (mutant)

3ci5, 3cip, 1nlv – DdGLS domain S1+actin

1nm1 - DdGLS domain S1+actin+Mg-ATP

3cjb - rGLS domain S1+rActin

3cjc - rGLS domain S1+rActin+DNAse I

1nmd - hGLS domain S1+actin+Ca+ATP

GLS C-terminal
2fh1, 2fh2, 2fh3, 2fh4 – hGLS C-terminal

1p8x - hGLS C-terminal+Ca

1p8z – hGLS fraction+rActin